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Anti-MITF Antibody (aa301-312, clone 21D1418) LS-C536

Ordering

Wt. Vol. Conc. Price
100 µg 200 µl - $335
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Mouse Monoclonal [clone 21D1418] (IgG1) to Human MITF
Human
Western blot
Unconjugated

Details

Human MITF
Mouse
IgG1 Monoclonal [21D1418]
Protein G purified

Applications

Western blot (3 - 5 µg/ml)

Specificity and Use

MITF antibody was raised against a synthetic peptide corresponding to amino acids 301-312 (PSTGLCSPDLVN) of itf. GenBank no. gi|1092105|prf||2022321A. The peptide immunogen sequence is 100% conserved between human, mouse, rat, pig and dog. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Hamster, Panda, Horse, Rabbit, Pig, Platypus (100%); Bovine, Elephant, Opossum, Turkey, Xenopus (92%); Bat, Goat, Chicken (83%).
aa301-312
Mitf produces, by alternative splicing, 10 different transcripts, all with introns, putatively encoding 10 different protein isoforms. Therefore, observed molecular weights may vary depending on MITF isoforms expressed. Users are encouraged to utilize the peptide immunogen sequence to gain further information about the isoforms recognized by the antibody.

Packaging

PBS containing 0.2% gelatin and 0.05% sodium azide.
Long term: -70°C; Short term: +4°C
For research use only.

About MITF

O75030 NM_000248 NP_000239.1

MITF Antibody, BHLHe32 Antibody, CMM8 Antibody, MI Antibody, Waardenburg syndrome, type 2A Antibody, WS2 Antibody, WS2A Antibody

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1).

Western blot

Western blot
Western blot analysis of Mitf in A375 lysate using antibody at 4 ug/ml.
 

Requested From: United States
Date Requested: 9/24/2016

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