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Key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU1 acts as a stimulator of MCU that senses calcium level via its EF-hand domains: enhances MCU opening at high Ca2+ concentration, allowing a rapid response of mitochondria to Ca2+ signals generated in the cytoplasm. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.
Gene Name: | mitochondrial calcium uptake 1 |
Synonyms: | MICU1, Ara CALC, CBARA1, CALC, EFHA3, Mitochondrial calcium uptake 1, Allergen Hom s 4, Atopy related autoantigen, Atopy-related autoantigen CALC |
Target Sequences: | NM_006077 NP_006068.2 Q9BPX6 |
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