Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MRC OX-3] (IgG1) to Rat MHC Class II RT1.Bu
Rat MHC Class II RT1.Bu
Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MRC OX-3]
Protein G purified
Flow Cytometry (0.02 µg/10E6 cells)
Specificity and Use
Rat thymocyte membrane glycoprotein.
Anti-rat RT1.Bu monoclonal antibody recognizes a polymorphic determinant on rat Ia present on Lewis, Wistar, and AO rat strains (although it is apparently expressed in lower amounts in AO rats) but not BN, DA, or PVG/c strains. This antibody also cross reacts with mouse strains (MHC haplotypes b and s) and analysis of recombinant mouse strains show that the determinant maps to the I-A region and correlates with mouse Ia specificity. Tested positive with Wistar, Buffalo, Fischer 344 and Lewis rats. Tested negative with Brown Norway and ACI rats.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.02% sodium azide, EIA grade BSA.
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.