Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MRC OX-3] (IgG1) to Rat MHC Class II RT1.Bu
Rat MHC Class II RT1.Bu
Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MRC OX-3]
Protein G purified
Flow Cytometry (0.02 µg/10E6 cells)
Specificity and Use
Rat thymocyte membrane glycoprotein.
Anti-rat RT1.Bu monoclonal antibody recognizes a polymorphic determinant on rat Ia present on Lewis, Wistar, and AO rat strains (although it is apparently expressed in lower amounts in AO rats) but not BN, DA, or PVG/c strains. This antibody also cross reacts with mouse strains (MHC haplotypes b and s) and analysis of recombinant mouse strains show that the determinant maps to the I-A region and correlates with mouse Ia specificity. Tested positive with Wistar, Buffalo, Fischer 344 and Lewis rats. Tested negative with Brown Norway and ACI rats.
PBS, 0.02% sodium azide, EIA grade BSA.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.