Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone AF6-88.5] (IgG2a) to Mouse MHC Class I H-2Kb
IHC - Frozen, Immunoprecipitation, Flow Cytometry (applications tested for the base form of this product only)
Mouse MHC Class I H-2Kb
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [AF6-88.5]
IHC - Frozen
Flow Cytometry (1:10 - 1:20)
(applications tested for the base form of this product only)
Specificity and Use
C57BL mouse splenocytes.
The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2 which are H-2K, H-2L and H-2D. The H- 2K gene is part of the murine H-2 complex on chromosome 17 and there are a large number of variant alleles of this gene. The antibody recognizes the H-2Kb determinant present on all nucleated cells of mice expressing this MHC class I haplotype. This product does not cross react with other haplotypes.
The applications listed have been tested for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.
PBS, 0.09% sodium azide
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles. Protect from light.