Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG2a,k) to Mouse MHC Class I H-2Db
IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Mouse MHC Class I H-2Db
Mouse (tested or 100% immunogen sequence identity)
IHC - Frozen
Specificity and Use
C3H. SW splenocytes.
Recognizes the alpha3 domain of H-2Db class I MHC antigen. Cross-reacts with the alpha3 domain of H-2Ld, H-2Dq and H-2Lq, but not H-2Kd or H-2Dd. Reactivity with haplotypes k, f, p, r, and s has not been observed.
Flow cytometry. Immunohistochemistry (acetone-fixed, frozen tissue sections only). Complement-dependent cytotoxicity assay. Flow Cytometry: 1 ug/1E6 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.