Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 28-14-8] (IgG2a,k) to Mouse MHC Class I H-2Db
IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Mouse MHC Class I H-2Db
Mouse (tested or 100% immunogen sequence identity)
IgG2a,k Monoclonal [28-14-8]
IHC - Frozen
Specificity and Use
C3H. SW mouse splenocytes.
Recognizes an epitope in the alpha3 domain of H-2Db. It cross-reacts with the alpha3 domain of H-2Ld, but not Kd or Dd, and with H-2Dq and/or Lq. Has been shown to block H-2Ld-specific and H-2Ld-restricted antigen-specific lysis of target cells by cytotoxic T lymphocytes, but it does not block recognition of H-2Ld-positive target cells by Ly-6G2-positive NK cells.