Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Methotrexate antibody was raised against methotrexate (4-amino-10-methylpteroyl-L-glutamic acid) conjugated via the carboxyl groups of the glutamic acid residue to KLH.
Recognizes Methotrexate, a drug originally manufactured as a chemotherapeutic agent for the treatment or a number of cancers. Methotrexate also acts as a disease-modifying anti-rheumatic drug used for the treatment of autoimmune conditions such as rheumatoid arthritis, Crohn's disease and vasculitis. Exhibits the following cross reactivities with related compounds:- Aminopterin, 18%; Folic acid, <0.01%; Dyhydrofolic acid, <0.01%; Tetrahydrofolic acid, <0.01%; N-5-Methyltetrahydrofolic acid, <0.01%; Folinic acid, <0.01%; N-(p-Aminobenzoyl)-L-glutamic acid, <0.01%;.