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The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.
Gene Name: | MDS1 and EVI1 complex locus |
Synonyms: | MECOM, AML1-EVI-1, EVI-1, EVI1, MDS1, MDS1 and EVI1 complex locus, MDS1-EVI1, Oncogene EVI1, AML1-EVI-1 fusion protein, Zinc finger protein Evi1, Myelodysplasia syndrome 1, PRDM3 |
Target Sequences: | NM_004991 NP_004982.2 Q03112 |
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