Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Marek's Disease Virus (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [14C8]
Specificity and Use
Marek's disease virus.
Detects Marek's Disease Virus (MDV), an oncogenic avian virus that is economically important in the chicken industry. MDV is a double stranded DNA herpesvirus, which is highly contagious, and results in aggressive T-cell lymphomas. Infection of MDV occurs via the respiratory tract, where its uptake by macrophages and dendritic cells allows it to be transported in the bloodstream to visceral organs and peripheral nerves. Here MDV results in neoplasms of the heart, liver, kidney and gonads, and polyneuritis. It can also lead to asymmetric paralysis of one or more limbs, difficulty of breathing, dilation of the crop and death in up to 80 percent of birds. Marek's disease is the only virus-induced tumor disease for which vaccination is available.