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Anti-MCM6 Antibody LS-C43024

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $520
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MCM6 Antibodies

Anti-MCM6 Antibody IHC-plus™ LS-B2008
Rabbit Polyclonal (IgG) to Mouse MCM6
Mouse, Human, Monkey, Bat, Bovine, Dog, Horse, Rabbit
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-MCM6 Antibody (C-Terminus) IHC-plus™ LS-B6803
Rabbit Polyclonal (IgG) to Human MCM6
Human, Bovine, Dog, Guinea pig, Horse, Rabbit
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human MCM6
Human
Western blot, Immunoprecipitation
Unconjugated

Details

Human MCM6
Rabbit
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (1:2000 - 1:10000)
  • Immunoprecipitation

Specificity and Use

MCM6 antibody was raised against synthetic peptide corresponding to a region within human MCM6 (locus link ID 4175).
Recognizes human DNA replication licensing factor MCM6, also known as minichromosome maintenance 6 (MCM6) or p105MCM. MCM6 is a 821 amino acid, ~115kD nuclear component of the MCM complex containing a single domain. MCM6 is involved in the initiation and control of eukaryotic DNA replication. Studies show that MCM4 forms a hexameric protein complex with MCM6 and 7, which has DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this complex by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. MCM6 has been noted to have elevated expression in Hodgkin's lymphoma and be a predictor of survival in patients with mantle cell lymphoma.
Western Blot: LS-C43024 detects a band of approximately 105 kD in Hela cell lysates.

Packaging

Tris-citrate/phosphate, pH 7.5, 0.09% sodium azide.
For research use only.

About MCM6

Q14566 NM_005915 NP_005906.2

MCM6 Antibody, Mis5 Antibody, MCG40308 Antibody, p105MCM Antibody

MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins.

Western blot

Western blot
Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti-Human MCM6 (LS-C43024).
 

Requested From: United States
Date Requested: 12/4/2016

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