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Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Gene Name: | minichromosome maintenance complex component 3 |
Synonyms: | MCM3, DNA replication factor MCM3, HCC5, HRlf beta subunit, p1-MCM3, RLF subunit beta, RLFB, p102, p1.h |
Target Sequences: | NM_002388 NP_002379.3 P25205 |
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