Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Western blot (1 - 10 µg/ml)
A 15-aa synthetic peptide near the N-terminus of Human MC5-R, coupled to KLH.
Recognizes Melanocortin Receptor 5. No significant sequence homology with other receptors. Species sequence homology: Human and rat: 93% (14/15 aa); Porcine, sheep and bovine: 73% (11/15 aa); chicken: 63%.
Suitable for use in ELISA and Western Blot. ELISA: 1:10000-1:1000000 using 50-100 ng control peptide/well. Western Blot: 1-10 ug/ml (ECL).
MC5R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH), and activates adenylate cyclase. This receptor controls multiple functions in the brain and in peripheral tissues, such as thermoregulation, immunomodulation, appetite control, and sexual behavior.