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Intramembrane proteolysis of sterol-regulatory element-binding proteins (SREBPs) within the first transmembrane segment thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Site-2 cleavage comes after site-1 cleavage which takes place in the lumenal loop.
Gene Name: | membrane-bound transcription factor peptidase, site 2 |
Family/Subfamily: | Protease , Metallopeptidase M50 |
Synonyms: | MBTPS2, BRESEK, Endopeptidase S2P, KFSDX, S2P, SREBPs intramembrane protease, IFAP |
Target Sequences: | NM_015884 NP_056968.1 O43462 |
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