Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Tau promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.
Western blot of mouse brain tissue lysate using 2 ug/ml Rabbit Anti-Tau (Phospho-Ser235) Polyclonal Antibody. Lane 1: Rabbit Anti-Tau (Phospho-Ser235) Polyclonal Antibody. Lane 2: Rabbit Anti-Tau (Phospho-Ser235) Polyclonal Antibody pre-incubated with non-phospho-peptide. Lane 3: Rabbit Anti-Tau (Phospho-Ser235) Polyclonal Antibody pre-incubated with phospho-peptide. Lane 4: Rabbit Anti-Tau (Phospho-Ser235) Polyclonal Antibody pre-incubated with generic phospho-serine containing peptide. The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG.