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MANF / ARMET

mesencephalic astrocyte-derived neurotrophic factor

MANF / ARMET is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Gene Name: mesencephalic astrocyte-derived neurotrophic factor
Synonyms: MANF, ARP, ARMET, Arginine-rich protein, Protein ARMET
Target Sequences: NM_006010 NP_006001.4 P55145

Publications (5)

1
Piperine ameliorates SCA17 neuropathology by reducing ER stress. Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Molecular neurodegeneration. 2018 January;13:4. (Human) [Full Text Article] [PubMed:29378605] [PMC:PMC5789626] Related Antibodies: LS-B2688.
2
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice. Galli E, Rossi J, Neumann T, Andressoo JO, Drinda S, Lindholm P. Science advances. 2019 October;9:14318. [Full Text Article] [PubMed:31586115] [PMC:PMC6778185] Related Antibodies: LS-B2688.
3
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, Lindahl M. Frontiers in endocrinology. 2019 November;10: [Full Text Article] [PubMed:31781038] [PMC:PMC6851024] Related Antibodies: LS-B2688.
4
MANF Is Neuroprotective in Early Stages of EAE, and Elevated in Spinal White Matter by Treatment With Dexamethasone. Jinhan Nam, Tapani K Koppinen, Merja H Voutilainen. Frontiers in cellular neuroscience. 2021 Jul;15:640084. [Full Text Article] [PubMed:34305531] [PMC:PMC8292680] Related Antibodies: LS-B2688.
5
MANF protein expression is upregulated in immune cells in the ischemic human brain and systemic recombinant MANF delivery in rat ischemic stroke model demonstrates anti-inflammatory effects. Jenni E Anttila, Olli S Mattila, Hock-Kean Liew, Kert Mätlik, Eero Mervaala, Päivi Lindholm, Maria Lindahl, Perttu J Lindsberg, Kuan-Yin Tseng, Mikko Airavaara. Acta neuropathologica communications. 2024 January;12:10. [Full Text Article] [PubMed:38229173] [PMC:PMC10792833] Related Antibodies: LS-B2688.
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☰ Filters
Antibodies (41)
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MANF / ARMET (75)
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MANF / ARMET Antibody - Anti-MANF / ARMET antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
MANF / ARMET Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded human liver using MANF antibody at dilution of 1:100 (40x lens).
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
20 µl/$287; 100 µl/$431
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MANF / ARMET ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
MANF / ARMET Antibody - Immunochemical staining of human MANF in human brain with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
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MANF / ARMET Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
MANF / ARMET Antibody - Immunohistochemistry of ARP antibody
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MANF / ARMET Rabbit anti-Human Polyclonal (1-50 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MANF / ARMET Protein - The ED50 was found to be <0.5ng/ml using dose dependent proliferation of human pancreatic cells.
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E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~18.4 kDa
40 µg/$291; 200 µg/$613; 1 mg/$2,269
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded human endometrial cancer using antibody at 1:100 dilution.
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MANF / ARMET Rabbit anti-Human Polyclonal (aa25-182) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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MANF / ARMET Rabbit-New Zealand White anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
100 µl/$393
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using MANF Polyclonal Antibody at dilution of 1:50.
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using MANF Polyclonal Antibody at dilution of 1:70.
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
MANF / ARMET Antibody - Detection limit for recombinant GST tagged ARMET is 0.03 ng/ml as a capture antibody.
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MANF / ARMET Mouse anti-Human Monoclonal (1D10) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
MANF / ARMET Rabbit anti-Human Polyclonal (aa23-51) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
MANF / ARMET Antibody - Western blot analysis of lysate from 293 cells, using MANF Antibody.
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MANF / ARMET Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MANF / ARMET Antibody - Rabbit antibody to MANF (20-70). IHC-P on paraffin sections of rat testis. The animal was perfused using Autoperfuser at a pressure of 110 mm Hg with 300 ml 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through a 0.2 micron filter. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.
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MANF / ARMET Rabbit anti-Mouse Polyclonal (aa20-70) Antibody
Mouse, Rat, Human
IHC
Unconjugated
100 µl/$393
Select
MANF / ARMET Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
Select
MANF / ARMET Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
Select
MANF / ARMET Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA
Unconjugated
100 µl/$412
Viewing 1-25 of 75 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).