Human MALT1

Mouse

Human (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

50

Unconjugated

Protein G purified

Unmodified

Recombinant protein corresponding to aa701-808 located within the C-Terminus of MALT1.

aa701-808

Recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), a 93kD paracaspase which has been reported to demonstrate proteolytic activity. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB. MALT1 was initially identified as a recurrent translocation t(11;18)(q21: q21) in mucosal-associated lymphomas, which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2. Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. The antibody is reported to recognize both MALT1 and the MALT1-API2 fusion protein.

• IHC - Paraffin (1:25 - 1:100)
• Western blot

PBS, 0.09% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9UDY8 NCBI: NM_006785 NP_006776.1