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Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASH1 together with TRIM27, leading to promote endosomal F-actin assembly (PubMed:23452853).
Gene Name: | MAGE-like 2 |
Synonyms: | MAGEL2, MAGE-like 2, Necdin-like protein 1, NDNL1, NM15, MAGE-like protein 2, Protein nM15 |
Target Sequences: | NM_019066 NP_061939.3 Q9UJ55 |
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