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Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
Gene Name: | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A |
Synonyms: | MAFA, HMafA, RIPE3b1, Transcription factor MafA, Transcription factor RIPE3b1 |
Target Sequences: | NM_201589 NP_963883.2 Q8NHW3 |
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