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Anti-MAdCAM-1 Antibody (clone 314G8) LS-C44686

Note: This antibody replaces LS-C57886

Ordering

Wt. Vol. Conc. Price
200 µg - 1 mg/ml $370
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular MAdCAM-1 Antibodies

Anti-MAdCAM-1 Antibody (clone 17FS) LS-C44691
Mouse Monoclonal [clone 17FS] (IgG1) to Human MAdCAM-1
Human
Western blot, Flow Cytometry, ELISA
Unconjugated
Anti-MAdCAM-1 Antibody (clone 314G8, Low Endotoxin) IHC-plus™ LS-B3316
Mouse Monoclonal [clone 314G8] (IgG1) to Human MAdCAM-1
Human
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Unconjugated, Low Endotoxin
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 314G8] (IgG1) to Human MAdCAM-1
Human
Flow Cytometry, ELISA
Unconjugated

Details

Human MAdCAM-1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [314G8]
Unconjugated
Protein G purified
Unmodified

Applications

  • Flow Cytometry (1:10 - 1:100)
  • ELISA

Specificity and Use

MAdCAM-1 antibody was raised against recombinant soluble MAdCAM-1-fc fusion protein.
Recognizes human mucosal addressin cell adhesion molecule 1 (MAdCAM-1) a 60kD cell surface protein that is involved in lymphocyte trafficking. MAdCAM-1 is expressed on high endothelial venules of Peyers patches and mesenteric lymph nodes. MAdCAM-1 expression has also been reported in the gut lamina propria but clone 314G8 does not recognize MAdCAM-1 in these tissues. Clone Reacts with the ligand-binding first Ig domain and reports suggest that a splice variant exists in the gut which is not recognized by clone 314G8. Clone 314G8 is reported to block the interaction of MAdCAM-1 with alpha 4 beta 7.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100ul.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
For research use only.

About MAdCAM-1

Q13477 NM_130762 AAC51354.1

MADCAM1 Antibody, HMAdCAM-1 Antibody, MACAM1 Antibody, MAdCAM-1 Antibody

Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.

Requested From: United States
Date Requested: 12/3/2016

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