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Anti-MAD1L1 / MAD1 Antibody (C-Terminus) LS-C16303

Catalog Size Price
LS-C16303-100 100 µl Unavailable

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100% Guaranteed
Rabbit Polyclonal (IgG) to Rabbit MAD1L1 / MAD1
Rabbit, Human, Mouse, Rat
Western blot
Unconjugated

Details

Rabbit MAD1L1 / MAD1
Rabbit
Rabbit, Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

Western blot (1:1000)

Specificity and Use

MAD1L1 / MAD1 antibody was raised against synthetic peptide (KLH-coupled) corresponding to the carboxy terminal region of Mad-1.
C-Terminus
Detects endogenous levels of Mad-1. Does not cross-react with other Mad family members at physiological levels. Species cross-reactivity: Rabbit, Mouse, Human.
Suitable for use in Western Blot. Western Blot: 1:1000. Incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4?C with gentle shaking, overnight.

Packaging

10 mM sodium HEPES, pH 7.5, 150 mM sodium chloride, 100 ug/ml BSA, 50% glycerol.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.

About MAD1L1 / MAD1

Q9Y6D9 NM_003550 NP_003541.2

MAD1L1 Antibody, HMAD1 Antibody, MAD1 Antibody, MAD1-like protein 1 Antibody, Tax-binding protein 181 Antibody, TP53I9 Antibody, PIG9 Antibody, HSMAD1 Antibody, Tax1-binding protein txbp181 Antibody, TXBP181 Antibody

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Requested From: 
Date Requested: 5/27/2018

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