The Immunohistochemistry Antibody Company
|Human, Mouse (tested or 100% immunogen sequence identity)|
|IHC - Paraffin (1:300), ICC (1:100)|
|LRRK2 antibody was raised against a genomic peptide made to an internal portion of the human LRRK2 protein (between residues 500-650) [UniProt Q5S007].|
|Store at 4°C in the dark.|
|For research use only.|
LRRK2 Antibody, AURA17 Antibody, PARK8 Antibody, RIPK7 Antibody, ROCO2 Antibody, DARDARIN Antibody, Leucine-rich repeat kinase 2 AntibodyPositively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.