The Immunohistochemistry Antibody Company
|Mouse (tested or 100% immunogen sequence identity)|
|IHC - Paraffin (2.5 µg/ml), Western blot (2 µg/ml)|
|LRRK2 antibody was raised against a synthetic peptide made to an internal region of the mouse LRRK2 protein sequence (between residues 900-1000). [Swiss-Prot# Q5S006]|
|50 mM sodium borate|
|Store at 4°C. Do not freeze.|
|For research use only.|
LRRK2 Antibody, AURA17 Antibody, PARK8 Antibody, RIPK7 Antibody, ROCO2 Antibody, DARDARIN Antibody, Leucine-rich repeat kinase 2 AntibodyPositively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner.