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LOXL4 / LOXC is a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Gene Name: | lysyl oxidase-like 4 |
Synonyms: | LOXL4, LOXC, Lysyl oxidase-like 4, Lysyl oxidase-like protein 4, Lysyl oxidase related C, Lysyl oxidase homolog 4 |
Target Sequences: | NM_032211 NP_115587.6 Q96JB6 |
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