Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
LD78 / CCL3L1 antibody was raised against synthetic peptide CNQVLSAPLAADT from an internal region of human CCL3L1 (NP_066286.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Gibbon (85%).
LS-E26906 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C112729. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Peptide ELISA: antibody detection limit dilution 1:8000. Western blot: Preliminary experiments in Human Bone Marrow and in Peripheral Blood Mononucleocyte lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).
LD78 / CCL3L1 is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry.