Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 7A4] (IgG1) to Human KRT16 / CK16 / Cytokeratin 16
IHC, IHC - Paraffin, Western blot
Mouse Monoclonal [clone LL025] (IgG1) to Human KRT16 / CK16 / Cytokeratin 16
Human KRT16 / CK16 / Cytokeratin 16
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [LL025]
Specificity and Use
BALB/C mice were injected with a synthetic peptide from the C- terminus of human cytokeratin 16.
Is specific to a 48 kD protein, which is identified as cytokeratin 16. Cytokeratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region. High concordance was found between the carcinomas immunostaining with the basal cell and the hyper proliferation related keratins.
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21.