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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KLRB1 / CD161 Antibody (clone B199.2) LS‑C14357
CD161 antibody LS-C14357 is an unconjugated mouse monoclonal antibody to human CD161 (KLRB1). Validated for Flow, IHC and IP.
Antibody
Catalog
Size
Price
LS-C14357-200
200 µg (1 mg/ml)
$590

Popular KLRB1 / CD161 Products

Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Rat
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Antibody
Species: Human
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Western Blot: CD161 Antibody (14F1F11) - Western blot analysis of a partial CD161 recombinant protein using CD161 antibody at 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Western blot
Western blot blot of extracts of various cell lines, using KLRB1 antibody.
Species: Human, Mouse, Rat
Applications: IHC, Western blot

Product Description

CD161 antibody LS-C14357 is an unconjugated mouse monoclonal antibody to human CD161 (KLRB1). Validated for Flow, IHC and IP.
About KLRB1 / CD161
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Q12918 NM_002258 NP_002249.1

KLRB1 Antibody, CD161 antigen Antibody, CLEC5B Antibody, CD161 Antibody, NKR-P1A Antibody, NKR Antibody, HNKR-P1A Antibody, NKR-P1 Antibody, NKRP1A Antibody


Specifications

Target
Human KLRB1 / CD161
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2b Monoclonal [B199.2]
Conjugations
Unconjugated. Also available conjugated with AP, Biotin, FITC, HRP, PE.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen
  • Immunoprecipitation
  • Flow Cytometry (1:50 - 1:100)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
KLRB1 / CD161 antibody was raised against cD161.
Specificity
Recognizes the human CD161 cell surface antigen, expressed by almost all NK cells and with a small subset of CD3+ve T cells. CD161 is a homodimeric cell surface protein, comprising two chains of 40-44kD.
Usage
Suitable for use in Flow Cytometry, Immunohistochemistry and Immunoprecipitation. Not suitable for use in Western Blot. Flow Cytometry: 1:50-1:100. Use 10 ul of the suggested working dilution to label 1E6 cells in 100ul. Immunohistochemistry: Frozen.
Presentation
PBS, pH 7.4, 0.1% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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