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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KLRB1 / CD161 Antibody (Azide‑free) LS‑C14352
CD161 antibody LS-C14352 is an unconjugated mouse monoclonal antibody to rat CD161 (KLRB1). Validated for Flow, Func, IP, RIA and WB.
Antibody
Catalog
Size
Price
LS-C14352-1000
1000 µg
$1,140

Popular KLRB1 / CD161 Products

Antibody
Species: Human
Applications: Flow Cytometry
Antibody
Species: Rat
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Antibody
Species: Human
Applications: IHC, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Western Blot: CD161 Antibody (14F1F11) - Western blot analysis of a partial CD161 recombinant protein using CD161 antibody at 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Western blot
Western blot blot of extracts of various cell lines, using KLRB1 antibody.
Species: Human, Mouse, Rat
Applications: IHC, Western blot

Product Description

CD161 antibody LS-C14352 is an unconjugated mouse monoclonal antibody to rat CD161 (KLRB1). Validated for Flow, Func, IP, RIA and WB.
About KLRB1 / CD161
Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Q12918 NM_002258 NP_002249.1

KLRB1 Antibody, CD161 antigen Antibody, CLEC5B Antibody, CD161 Antibody, NKR-P1A Antibody, NKR Antibody, HNKR-P1A Antibody, NKR-P1 Antibody, NKRP1A Antibody


Specifications

Target
Rat KLRB1 / CD161
Host
Mouse
Reactivity
Rat (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Azide-free
Applications
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry (1:50 - 1:100)
  • Functional Assay
  • Radioimmunoassay
Immunogen
KLRB1 / CD161 antibody was raised against purified splenic NK cells from the LEW rat strain.
Specificity
Recognizes the rat CD161 protein (also known as NKR-PI) a 60kD glycoprotein expressed on rat NK cells and T cell subpopulations. This antibody competes with clone 3.2.3 for binding to the antigen. Clone 3H1914 stimulates NK mediated cytotoxicity in a manner identical to clone 3.2.3.
Usage
Immunoprecipitation. Western Blot. Radioimmunoassay. Functional Studies. Flow Cytometry: 1:50-1:100. The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Presentation
PBS
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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