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May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1.
Gene Name: | klotho |
Synonyms: | KL, Klotho |
Target Sequences: | NM_004795 NP_004786.2 Q9UEF7 |
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