Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 190IIC311] (IgG2a) to Human KIR2DL3 / GL183
Western blot, Flow Cytometry, ELISA
Human KIR2DL3 / GL183
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [190IIC311]
Protein G purified
Western blot (1 µg/ml)
IHC - Paraffin
Specificity and Use
KIR2DL3 / GL183 antibody was raised against recombinant human KIR2DL3.
Applications include flow cytometry (5-10 ug/10^6 cells), ELISA (1:1000 when tested against the immunizing protein) and western blot analysis (1 ug/ml). The antibody has been tested by immunofluorescent staining with flow cytometric analysis and by Western blot analysis to assure specificity and reactivity.1 Since application vary, however, each investigation should titrate the reagent to obtain optimal results.
PBS, pH 7.4, 0.2 µm filtered
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2).