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Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration By similarity. Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.
Gene Name: | kinase D-interacting substrate, 220kDa |
Synonyms: | KIDINS220, ARMS, KIAA1250 |
Target Sequences: | AB033076 NP_065789.1 Q9ULH0 |
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