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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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KIAA1811 / BRSK1 Antibody LS‑C187781
Antibody
BRSK1 antibody LS-C187781 is an unconjugated rabbit polyclonal antibody to BRSK1 (KIAA1811) from human, mouse and rat. Validated for IHC and WB.
Catalog
Size
Price
LS-C187781-100
100 µg (1 mg/ml)
Unavailable

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Product Description

BRSK1 antibody LS-C187781 is an unconjugated rabbit polyclonal antibody to BRSK1 (KIAA1811) from human, mouse and rat. Validated for IHC and WB.
About KIAA1811 / BRSK1
Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Q8TDC3 AB058714 BAB47440.1

BRSK1 Antibody, BR serine/threonine kinase 1 Antibody, Brain-selective kinase 1 Antibody, KIAA1811 Antibody, HSAD1 Antibody, Protein kinase SAD1A Antibody, SAD1 Antibody, SadB kinase short isoform Antibody, SAD1 homolog Antibody, SAD1 kinase Antibody, SADB Antibody


Specifications

Target
Human KIAA1811 / BRSK1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (5 µg/ml)
  • Western blot (0.5 - 1 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
A peptide corresponding to a 28 amino acid sequence from near the centre of Human BRSK1.
Specificity
Recognizes human BR serine-threonine kinase 1 (BRSK1), a cytoplasmic and nuclear protein belonging to the protein kinase super family. BRSK1 is a widely expressed protein, with highest levels being detected in the brain and testis. It is essential for the polarization forebrain neurons which results in the distinct properties of axons and dendrites. BRSK1 is involved in the regulation of G2/M arrest and functions as a checkpoint kinase following UV- or methyl methane sulfonate (but not IR-) induced DNA damage. BRSK1 phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Multiple isoforms of BRSK1 have been identified.
Presentation
PBS, 0.02% sodium azide
Storage
4°C or -20°C, Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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