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Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
Gene Name: | lysine (K)-specific demethylase 4D |
Synonyms: | KDM4D, JMJD2D, JHDM3D, Lysine-specific demethylase 4D, Jumonji domain containing 2D |
Target Sequences: | NM_018039 NP_060509.2 Q6B0I6 |
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