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Anti-ITGB4 / Integrin Beta 4 Antibody (aa1809-1822) LS-C14098

Ordering

Wt. Vol. Conc. Price
- 100 µl - $560
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Rabbit Polyclonal (IgG) to Human ITGB4 / Integrin Beta 4
Human, Rat
IHC - Frozen, Immunoprecipitation
Unconjugated

Details

Human ITGB4 / Integrin Beta 4
Rabbit
Human, Rat (tested or 100% immunogen sequence identity)
Mouse, Bovine, Hamster (at least 90% immunogen sequence identity)
IgG Polyclonal
Antiserum

Applications

IHC - Frozen, Immunoprecipitation

Specificity and Use

ITGB4 / Integrin Beta 4 antibody was raised against synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human b4 integrin subunit (1). The sequence used is NH2- (K)GTLSTHMDQQFFQT-amide. The lysine (K) is not in the b4 sequence and was added to conjugate the peptide to the protein carrier. Percent identity by BLAST analysis: Human (100%); Mouse, Rat, Hamster, Bovine (93%); Gorilla, Gibbon, Horse (86%).
aa1809-1822
Recognizes human b4 integrin as determined by immunoprecipitation. The epitope recognized is on the cytoplasmic domain of the protein and is thus intracellular. No cross-reactivity to other integrin b subunits. Species cross-reactivity: rat and mouse.
Suitable for use in Immunoprecipitation. Immunoprecipitation: Labeled cell extract 5 ul of serum is sufficient to precipitate a6b4 from 1-2 x 1E6 cells. In some cases immunoprecipitation from 35S methionine labeled cells originates two bands of 95 and 55kD of unknown origin in addition to the 200kD and 140kD bands corresponding to b4 and a6.

Packaging

Supplied as a liquid, 0.05% sodium azide.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About ITGB4 / Integrin Beta 4

P16144 NM_000213 NP_000204.3

ITGB4 Antibody, CD104 Antibody, Integrin beta-4 Antibody, Integrin Beta 4 Antibody, gp150 Antibody, CD104 antigen Antibody, Integrin beta-4 subunit Antibody, Integrin, beta 4 Antibody

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins.

Immunohistochemistry

Immunohistochemistry
IHC of rat vaginal epithelium using LS-C14098
 

Requested From: United States
Date Requested: 9/29/2016

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