Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone K2D5] (IgG1,k) to Human ITGB1 / Integrin Beta 1 / CD29
IHC - Paraffin, Western blot, ELISA
Mouse Monoclonal (IgG1) to Human ITGB1 / Integrin Beta 1 / CD29
Western blot, Flow Cytometry, ELISA
Human ITGB1 / Integrin Beta 1 / CD29
Human, Mink (tested or 100% immunogen sequence identity)
Protein G purified
Flow Cytometry (1:25 - 1:50)
ELISA (10 µg/ml)
Specificity and Use
Purified human beta1 integrin preparation from HT1080 fibrosarcoma cell extract.
Recognizes the human beta1 integrin. Has been shown to bind to a ligand induced binding site antibody, binding being increased in the presence of fibronectin ligand. Also enhances alpha 5 - beta 1 - fibronectin interactions.
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.