Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Human ITGB1 / Integrin Beta 1 / CD29
Western blot, Flow Cytometry, ELISA
Human ITGB1 / Integrin Beta 1 / CD29
Human, Mink (tested or 100% immunogen sequence identity)
Protein G purified
Flow Cytometry (1:25 - 1:50)
ELISA (10 µg/ml)
Specificity and Use
ITGB1 / Integrin Beta 1 / CD29 antibody was raised against purified human beta1 integrin preparation from HT1080 fibrosarcoma cell extract.
Recognizes the human beta1 integrin. Has been shown to bind to a ligand induced binding site antibody, binding being increased in the presence of fibronectin ligand. Also enhances alpha 5 - beta 1 - fibronectin interactions.
Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin.