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Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, this protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. This protein is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation.
Gene Name: | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) |
Family/Subfamily: | Integrin , not assigned-Integrin |
Synonyms: | ITGAE, CD103, CD103 antigen, Integrin alpha-E, HML-1 antigen, Integrin alpha-IEL, Alpha polypeptide), Mucosal lymphocyte 1 antigen, HUMINAE |
Target Sequences: | NM_002208 NP_002199.3 P38570 |
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