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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found.
Gene Name: | isoleucyl-tRNA synthetase |
Synonyms: | IARS, IARS1, ILRS, IRS, Isoleucyl-tRNA synthetase, PRO0785, ILERS |
Target Sequences: | NM_013417 NP_038203.2 P41252 |
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