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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Integrin AlphaV Beta6 Antibody LS‑C24778 Best Seller
Antibody
Integrin AlphaV Beta6 antibody LS-C24778 is an unconjugated mouse monoclonal antibody to Integrin AlphaV Beta6 from human, mouse and rat. Validated for Flow, Func and IP.
Catalog
Size
Price
LS-C24778-100
100 µg (1 mg/ml)
Unavailable

Popular Integrin AlphaV Beta6 Products

Antibody
Species: Human, Monkey
Applications: IHC, IHC - Frozen, ICC, Flow Cytometry
Antibody
Species: Human, Monkey
Applications: IHC, ICC, Flow Cytometry
Antibody
Species: Human, Monkey
Applications: IHC, ICC, Flow Cytometry
Antibody
Species: Human, Monkey
Applications: IHC, ICC, Flow Cytometry

Product Description

Integrin AlphaV Beta6 antibody LS-C24778 is an unconjugated mouse monoclonal antibody to Integrin AlphaV Beta6 from human, mouse and rat. Validated for Flow, Func and IP.

Specifications

Target
Mouse Integrin AlphaV Beta6
Host
Mouse
Reactivity
Mouse, Human, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Immunoprecipitation
  • Flow Cytometry
  • Functional Assay
  • (applications tested for the base form of this product only)
Failed Applications
  • IHC
  • Western blot
Immunogen
Immunization of beta 6 knockout mice with wild type murine keratinocytes.
Specificity
Recognizes mouse integrin alpha V beta 6. Blocks activity against mouse and human alpha V beta 6. Does not recognize alpha V or other alpha V integrins. Species cross-reactivity: Human, rat and mouse. Because the antibody was raised in knockout mice, it is likely to recognize the receptor in other species.
Usage
Suitable for use in Flow Cytometry, Immunoprecipitation and Function Blocking. Not suitable for use in Western Blot and Immunohistochemistry. Flow Cytometry (effective for mouse and human): Use buffers containing 1 mM Mg, since the epitope recognized is divalent cation-dependent. Immunoprecipitation: Effective. Protein G or rabbit anti-mouse IgG recommended for capture. Function blocking: Inhibition of alpha V beta 6-mediated cell adhesion and cell migration are achieved at a concentration of 100 ug/ml using beta 6 transfected cells tested against TGFbeta LAP. Note: Cell lines adhere to simple ligands (e. g. fibronectin) using more integrins than alphav/beta6, so it would be necessary to also block other integrins (e. g. with anti-beta1 antibody) to see any effect of this antibody on adhesion to fibronectin. For example, H441 cells, which naturally express high levels of alphaV/beta6, may be used as a positive control.
Presentation
PBS. No preservatives added.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/18/2018

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