Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Human Integrin Alpha V Beta 3
Human Integrin Alpha V Beta 3
Human, Chicken (tested or 100% immunogen sequence identity)
Protein G purified
Specificity and Use
Osteoclasts from osteoclastomas.
Recognizes the intact complex formed between the CD51 and CD61 molecules (alpha V and beta 3 integrins). This complex binds vitronectin at the RGD sequence and can also bind fibrinogen, von Willebrand factor, thrombospondin, fibronectin, osteopontin and collagen. Reacts with osteoclasts, placenta, melanoma cell lines and weakly with platelets. Species cross Reactivity: Human, chicken. Does not cross-react with porcine, lapine or bovine tissue.
Suitable for use in Flow Cytometry. Flow Cytometry: Neat. Use 10 ul to label 1E6 cells in 100ul.
100 tst deionized water
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C