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B001/B101
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Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR.
Gene Name: | insulin induced gene 2 |
Synonyms: | INSIG2, Insulin induced protein 2, INSIG2 membrane protein, Insulin-induced gene 2 protein, INSIG-2, Insulin induced gene 2 |
Target Sequences: | AF125392 Q9Y5U4 Q9Y5U4 |
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