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RNA-binding factor that may recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation in cancer cells. Binds to beta-actin/ACTB and MYC transcripts. Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs.
Gene Name: | insulin-like growth factor 2 mRNA binding protein 3 |
Synonyms: | IGF2BP3, CT98, IGF II mRNA binding protein 3, IMP-3, KOC1, IGF-II mRNA-binding protein 3, IGF2 mRNA-binding protein 3, VICKZ family member 3, Cancer/testis antigen 98, HKOC, VICKZ3 |
Target Sequences: | NM_006547 NP_006538.2 O00425 |
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