Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 6H6] (IgG1,k) to Human IL3RA / CD123
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Human IL3RA / CD123
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [6H6]
Protein G purified
IHC - Frozen
Specificity and Use
IL3RA / CD123 antibody was raised against tissue / cell preparation. IL3R transfected COS cells.
Species cross-reactivity: Cross-reacts with Human.
Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunohistochemistry. Immunohistochemistry: Frozen sections. Western Blot: Detects a band at ~70kD. Flow Cytometry: Use 1 ug to label 1x1E6 cells in 100ul.
IL3RA / CD123 is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3.