Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey (tested or 100% immunogen sequence identity)
Protein G purified
Western blot (1:500)
Specificity and Use
IL23R antibody was raised against a synthetic peptide corresponding to amino acids 439-455 (EIFIPEHKPTDYKKENT) of human IL-23R was used as immunogen, Genbank no NP_653302. Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (88%).
A synthetic peptide corresponding to amino acids 439-455 (EIFIPEHKPTDYKKENT) of human IL-23 receptor was used as immunogen, Genbank no NP_653302.
PBS, 0.05% sodium azide.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.