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Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene Name: | interleukin 17 receptor A |
Family/Subfamily: | Interleukin |
Synonyms: | IL17RA, CANDF5, CD217 antigen, CDw217, CD217, HIL-17R, IL-17RA, IL17R, Interleukin-17 receptor A, IL-17 receptor, IL-17 receptor A, Interleukin 17 receptor, Interleukin 17 receptor A |
Target Sequences: | NM_014339 NP_055154.3 Q96F46 |
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