Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human, Rat (tested or 100% immunogen sequence identity)
Western blot (1 - 3 µg/ml)
Specificity and Use
IL17RA antibody was raised against synthetic peptide C-DQEKHGDDSKIN from an internal region of mouse IL17RA / IL-17RA (NP_032385.1). Percent identity with other species by BLAST analysis: Mouse (100%), Rat (92%).
Western Blot: Approx 110kD band observed in Rat Kidney lysates (calculated MW of 96.1kD according to Mouse NP_032385.1 and of 97.9kD according to Rat NP_001101353.2). Recommended concentration: 1-3 ug/ml.
Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis.