Human IL17

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Purified

Unmodified

Recombinant human IL-17.

Recognizes human IL-17 (Interleukin-17/17A), a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.

• IHC - Paraffin
• Immunofluorescence
• Western blot (0.1 - 0.2 µg/ml)
• ELISA (0.5 - 2 µg/ml)

ELISA: May be used in an indirect ELISA or as the capture reagent in a sandwich ELISA. Western Blot: May be used under either reducing or non-reducing conditions.

PBS

Distilled Water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add azide.

Before reconstitution store at 4°C. After reconstitution store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.