Mouse IL17

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG1 Monoclonal

TC11-8H4

Unconjugated

Purified

Unmodified

Recombinant mouse IL-17 expressed in E. coli.

Recognizes mouse Interleukin 17, a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction. Has been successfully used for the identification of IL-17 secreting cells in a murine anti-tumor immunity model by ELISPOT analysis.

• ELISA

BBS

Store at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

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