(tested or 100% immunogen sequence identity)
IL17 antibody was raised against e. coli-expressed, recombinant mouse IL-17A
Recognizes mouse Interleukin 17, a 32kD disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family (classified as IL-17A to IL-17F), and signal through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
ELISA: This antibody can be used in a sandwich ELISA with LS-C41752
as a detection antibody.
Aliquot and store at -20°C. Avoid freeze-thaw cycles.
This antibody carries the LSBio 100% Guarantee.