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IL12 is a cytokine produced by immune cells as a response to antigenic stimulation. It serves as an essential inducer of Th1 cell development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
Target Name: | IL12 / Interleukin 12 |
Target Abbreviation: | IL-12 |
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