Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 3E1] (IgG1) to Human IL-1B / IL-1 Beta
IHC, IHC - Paraffin, Immunofluorescence, Western blot
Rabbit Polyclonal to Human IL-1B / IL-1 Beta
Human, Mouse, Rat
IHC, Western blot, ELISA
Human IL-1B / IL-1 Beta
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Protein A purified
IHC (1:100 - 1:500)
Western blot (1:100 - 1:500)
ELISA (1:500 - 1:1000)
Specificity and Use
KLH-conjugated synthetic peptide from the N-terminal region of mouse IL-1 beta.
Interleukin-1 (IL-1) is a cytokine produced by activated macrophages. IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 is involved in the inflammatory response as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
IL-1 Beta is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis.