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ICAM‑1 / CD54 Antibody (clone 4D10) LS‑C96264
CD54 antibody LS-C96264 is an unconjugated mouse monoclonal antibody to human CD54 (ICAM-1). Validated for IHC.
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Review This ProductPopular ICAM-1 / CD54 Products
Species:
Human, Rat, Bovine
Applications:
IHC, IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Species:
Human, Pig
Applications:
IHC - Paraffin, IHC - Frozen, Immunoprecipitation, Flow Cytometry
Species:
Human, Baboon, Monkey, Cynomolgus
Applications:
IHC, IHC - Frozen, Western blot, Immunoprecipitation, ELISA
Species:
Human
Applications:
Western blot, Flow Cytometry, ELISA
Species:
Human
Applications:
Flow Cytometry, ELISA
Product Description
CD54 antibody LS-C96264 is an unconjugated mouse monoclonal antibody to human CD54 (ICAM-1). Validated for IHC.
About ICAM-1 / CD54
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
P05362
NM_000201
NP_000192.2
ICAM1 Antibody, BB2 Antibody, CD54 antigen Antibody, CD54 Antibody, ICAM-1 Antibody, p3.58 Antibody
Specifications
Target
ICAM-1 / CD54
Host
Mouse
Reactivity
Human
(tested or 100% immunogen sequence identity)
Clonality
Monoclonal
[4D10]
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
- IHC
- IHC - Paraffin (1:800)
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Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
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Immunogen
ICAM-1 / CD54 antibody was raised against cultured human endothelial cells
Specificity
The antigen is CD54, the antibody recognizes an epitope on domain 1 of the molecule as tested on transfectants. Biochemistry: Clone 1304 stains a 95kD single chain integral membrane glycoprotein. The epitope is stable against acetone or paraformaldehyde fixation. ICAM 1 also functions as a rhinovirus receptor. Antigen distribution: Isolated cells: ICAM-1 expression can be induced on endothelial cells by in vitro stimulation with IL-1, TNF-alpha and IFN-gamma. Tissue sections: In inflamed lesions, the antibody reacts with stimulated endothelial cells, epithelial cells and fibroblasts and with haemopoietic cells such as macrophages, dendritic cells in Peyer's patches, lymph nodes and tonsils. Specificity: Human: CD54. Other: not tested.
Presentation
Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal
Reconstitution
0.5ml distilled water
Storage
Store at 4°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
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Requested From:
Date Requested: 6/23/2018
Date Requested: 6/23/2018
