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Anti-ICAM-1 / CD54 Antibody (clone 4D10) LS-C96264
Most Popular ICAM-1 / CD54 Antibodies
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Details
| ICAM-1 / CD54 | |
| Mouse | |
| Human (tested or 100% immunogen sequence identity) | |
| Monoclonal [4D10] | |
| Unconjugated | |
| Affinity purified | |
| Unmodified |
Applications
| IHC - Paraffin (1:800) |
Specificity and Use
| ICAM-1 / CD54 antibody was raised against cultured human endothelial cells | |
| The antigen is CD54, the antibody recognizes an epitope on domain 1 of the molecule as tested on transfectants. Biochemistry: Clone 1304 stains a 95kD single chain integral membrane glycoprotein. The epitope is stable against acetone or paraformaldehyde fixation. ICAM 1 also functions as a rhinovirus receptor. Antigen distribution: Isolated cells: ICAM-1 expression can be induced on endothelial cells by in vitro stimulation with IL-1, TNF-alpha and IFN-gamma. Tissue sections: In inflamed lesions, the antibody reacts with stimulated endothelial cells, epithelial cells and fibroblasts and with haemopoietic cells such as macrophages, dendritic cells in Peyer's patches, lymph nodes and tonsils. Specificity: Human: CD54. Other: not tested. |
Packaging
| Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal | |
| 0.5ml distilled water | |
| Store at 4°C. | |
| For research use only. |
About ICAM-1 / CD54
P05362
NM_000201
NP_000192.2
ICAM1 Antibody, BB2 Antibody, CD54 antigen Antibody, CD54 Antibody, ICAM-1 Antibody, p3.58 Antibody
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. In case of rhinovirus infection acts as a cellular receptor for the virus.
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Requested From:
Date Requested: 8/21/2017
Date Requested: 8/21/2017
